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Ear, nose and throat and audiology

The ear, nose and throat (ENT) department at Guy's Hospital participates in various clinical research that helps in the treatment and management of ENT disorders. This includes diseases of the ear, nose and throat, as well as hearing and balance problems. These studies are supported by the National Institute for Health Research and commercial drug companies.

Trials looking for volunteers

We are currently looking for volunteers to take part in the following studies. Eligible participants will need a referral from their GP. If you are eligible and would like to participate, please email for more information.

  • MACRO – defining best management in adult
    chronic rhinosinusitis

    The MACRO trial is part of a large programme of work funded by the government. It aims to find out which treatments work best for adults with chronic rhinosinusitis (CRS), with and without nasal polyps.

    CRS is a long-term sinus disease affecting 1 in 10 adults in the UK. The MACRO trial will investigate 3 different treatment options for patients with CRS. All participants who join the MACRO trial will be asked to use standard care (intranasal medications), which are considered the current best practice for management of CRS.

    For more information visit the MACRO website or email

    Please ask your doctor to refer you to Guy's Hospital if you are interested in taking part.

    The principal investigator is Professor Claire Hopkins.

  • BC105 – performance of the ponto BHX implant system

    This research study is to gather information on how well and how safely the bone anchored hearing system (BAHS) treatment works.

    The principal investigator is Irumee Pai.

  • BC108 – ponto implantation using a minimally invasive surgical technique

    This research study is to gather information on how well and how safely a new development in the surgery for bone anchored hearing system (BAHS) treatment works.

    The principal investigator is Harry Powell.

  • MDR – patient registry for people with Ménière’s disease

    The Ménière's Disease Registry records and analyses information about the health and treatment of people with Ménière's disease in England. It also records the number of people in England with Ménière's disease and where they are. Participants complete questionnaires about how Ménière's disease affects them.

    The principal investigator is Professor Louisa Murdin.

  • SeaSHeL – prognostic factors for outcomes of idiopathic sudden onset sensorineural hearing loss

    Each year, around 15,000 people in the United Kingdom experience sudden onset hearing loss. When the cause for the hearing loss is not clear, the condition is called idiopathic 'sudden onset sensorineural hearing loss' (SSHNL).

    We are carrying out this study to identify how patients with SSHNL are being treated, and how they cope with the condition afterwards. This will help us understand the condition better and help the development of new treatments. Participants will complete 2 questionnaires.

    The principal investigator is Dr Hannah Blanchford

Ongoing studies

Read about ongoing studies. Please note we are no longer recruiting volunteers for these trials.

  • Coronavirus (COVID-19) and anosmia

    The purpose of the study is to better understand the role of the loss of sense of smell (anosmia) as a key symptom of coronavirus (COVID-19).

    The study includes a questionnaire about how often loss of smell occurs in COVID-19 patients and we may ask you to identify different smells using a validated smell test.

    On the basis of the questionnaire and the smell test result, we may invite you to participate in our treatment study. This is a randomised controlled trial (RCT), where we will assess the effectiveness of smell training to treat the loss of sense of smell.

    The principal investigator is Professor Claire Hopkins.

Completed studies

These studies are closed and no longer open to volunteers.

  • EVOTION 2020 – hearing loss

    EVOTION investigates self-management and learning from user patterns, auditory training, and prevention of noise-induced hearing loss. Researchers in the EVOTION project include hearing care professionals working in public and private clinics in the United Kingdom and in Greece, data and security scientists, and policy makers.

    The project will show how individual data from hearing aid users, pooled into a large data set, improves the outcomes of hearing healthcare for the individual users. Furthermore, EVOTION aims to lead to evidence-based practices and evidence-informed public health policies.

    The project uses open-source big data analysis tools to process the data coming from different vendors and domains as a first step towards open data and open research. The EVOTION project generates evidence to support integrated decision support in a platform for the creation of holistic hearing loss management policies.

    The project is funded by the European Commission Horizon 2020, has 13 partners from seven EU countries including Guy's and St Thomas' NHS Foundation Trust and is coordinated by Oticon (Denmark).

    For more information, visit the EVOTION 2020 website.

    The principal investigator is Professor Louisa Murdin.

  • KOSNAR – non-allergic rhinitis

    A medical device study of kinetic oscillation stimulation by the chordate system S101 in the treatment of non-allergic rhinitis. This study is sponsored by Chordate Medical.

    The principal investigator is Professor Claire Hopkins.

  • NAIROS – nasal airway obstruction study

    This study will investigate whether surgery (septoplasty) or medical management is the best method for treating problems with a blocked nose (nasal airway obstruction). 

    Patients who agree to take part are randomly allocated to either medical management or surgery. Information will be also be collected on health, quality of life, concerns, and costs to patients.

    For more information visit the visit  the NAIROS website or email

    The principal investigator is Professor Claire Hopkins.

  • NATTINA – recurrent tonsillitis

    In the NATTINA study we want to investigate the effectiveness and costs of tonsil removal surgery (tonsillectomy) compared with conservative management (deferred surgery) in adults with frequent sore throats.

    Participants are randomly split into 2 groups – surgery and conservative management. We plan to compare the number of sore throat days after each approach which may help us decide who can benefit most from surgery.

    Visit the NATTINA website for more information and to watch the information DVD.

    The principal investigator is Professor Claire Hopkins.

  • OPTINOSE – nasal polyp study

    Study to gather information on the safety and effectiveness of giving participants fluticasone propionate through the nose using a new device.

    The principal investigator is Professor Claire Hopkins.

  • OTONOMY – Ménière's disease study

    The purpose of this study was to test how well and how safely the OTO-104 (study drug) works compared to a placebo (a 'dummy pill') in participants with Ménière's disease. OTO-104 contains an ingredient called dexamethasone, which is a commonly used steroid. When OTO-104 is injected into the ear, OTO-104 turns into a gel and allows the steroid to stay in the ear for several weeks.

    The principal investigator is Professor Louisa Murdin.

  • SYNAPSE – nasal polyp study with mepolizumab

    This is a study to test the effect of mepolizumab in patients with severe bilateral nasal polyps, sponsored by GlaxoSmithKline (GSK). Mepolizumab is a type of medicine called a monoclonal antibody that is made in the laboratory. It works by blocking a protein in the body called interleukin-5, which people with severe nasal polyps can have more of in their body.

    This study will look at how people react to and how the body uses mepolizumab. Participants will be randomly split into 2 groups to receive either the active drug and placebo (a 'dummy pill').

    The study drug, mepolizumab, is not approved yet for doctors to treat patients with nasal polyps, however it is used for patients with severe asthma in several countries.

    The principal investigator is Professor Claire Hopkins.

  • SINUS-24 – nasal polyp study with dupilumab

    The purpose of this study is to see how well and how safely a study drug called dupilumab works in people who have nasal polyps. The study compares dupilumab to a placebo (or 'dummy drug'), and both treatments are given by an injection under the skin every 2 weeks for 24 weeks.

    These injections are given in addition to a nasal spray which contains the steroid mometasone furoate. This medicine is used to control nasal polyps. This study is being sponsored by the pharmaceutical company, Sanofi.

    The principal investigator is Professor Claire Hopkins.

  • TACTT3/AMPACT2 – tinnitus study

    The purpose of this research study was to find out how well and how safely a treatment with AM-101 (study drug) works when given into the middle ear for tinnitus. The active pharmaceutical ingredient of AM-101 is Esketamine hydrochloride.

    The principal investigator is Rupert Obholzer.