Predictive testing

You can have predictive testing if genetic testing has already been done in your family and has confirmed that a mutation (fault) in the TP53 gene is present in your family. This is called a familial Li-Fraumeni syndrome mutation. 

You can have a test to see if you have inherited the same mutation. This is called a predictive test and it involves taking a blood sample.

Before we offer you a predictive test we discuss with you what the test could mean for you and your family. We give you the opportunity to ask questions. Your genetics clinician will talk to you about the many things to consider before deciding. You can read our suggestions to help you decide. 

Predictive gene tests take up to 4 to 6 weeks once your blood sample has been received and we have all the information needed to carry out the test. Once the result is ready, we contact you and offer further appointments, if needed.

Results of predictive testing

Predictive testing will confirm that either:

You have not inherited the familial Li-Fraumeni syndrome mutation

• Although there is an inherited tendency to develop cancer in your family, you have not inherited it.
• Your own risk of developing Li-Fraumeni syndrome-related cancers is not higher than anyone in the general population.
• As you do not have the mutation you cannot pass it on to your children. 

You have inherited the familial Li-Fraumeni syndrome mutation

• You will have an increased chance of developing the cancers associated with a mutation in the TP53 gene.
• There is an up to 90% (9 out of 10) risk of developing specific types of cancer by the age of 60.